Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation.

@article{Murphy2004InterchainPI,
  title={Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation.},
  author={Brona M. Murphy and Emma M. Creagh and Seamus J. Martin},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 35},
  pages={
          36916-22
        }
}
Caspases coordinate the internal demolition of the cell that is seen during apoptosis. Proteolytic processing of caspases is observed during apoptosis, and this correlates with conversion of inactive caspase proenzymes into their active two-chain forms. However, recent studies have suggested that caspase-8 is activated through dimerization and that interchain proteolysis is not sufficient for activation of this caspase. This proposal casts doubt upon whether caspase-8 is productively activated… CONTINUE READING

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Epilepsy and apoptosis pathways.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2005
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