Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells

@article{Saha2021IntercellularNM,
  title={Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells},
  author={Tanmoy Kumar Saha and Chinmayee Dash and Ruparoshni Jayabalan and Sachin K. Khiste and Arpita Kulkarni and Kiran Kurmi and Jayanta Mondal and Pradip K. Majumder and Aditya Bardia and Hae Lin Jang and Shiladitya Sengupta},
  journal={Nature Nanotechnology},
  year={2021},
  volume={17},
  pages={98-106}
}
Cancer progresses by evading the immune system. Elucidating diverse immune evasion strategies is a critical step in the search for next-generation immunotherapies for cancer. Here we report that cancer cells can hijack the mitochondria from immune cells via physical nanotubes. Mitochondria are essential for metabolism and activation of immune cells. By using field-emission scanning electron microscopy, fluorophore-tagged mitochondrial transfer tracing and metabolic quantification, we… 

Immune Cell Metabolic Fitness for Life

TLDR
This review highlights many of the key findings leading to this generation’s CAR T treatments and the work currently being done to advance immunotherapy, to empower not just T cells but other immune cells as well against a variety of cancers.

Miro proteins and their role in mitochondrial transfer in cancer and beyond

TLDR
The evidence for and propose possible roles of Miro proteins in nanotube-mediated transfer as well as in cancer cell migration and metastasis are summarized, both processes being tightly connected to cytoskeleton-driven mitochondrial movement and positioning.

Immune Cells vs. Cancer Cells: A Microscopic Energy Battle

TLDR
A new theory in oncology, the ‘energy battle’ between cancer and immune cells is provided, which alludes each party with a higher energy level can be the winner.

New Immunometabolic Strategy Based on Cell Type-Specific Metabolic Reprogramming in the Tumor Immune Microenvironment

TLDR
If tumor cells prevail against immune cells for nutrients, the former gains immune resistance, and a strategy is needed to selectively suppress such resistant tumor cells, and the concept of cell type-specific metabolic pathway inhibition is a potent new strategy in anticancer immunotherapy.

Mitochondrial Proteins as Source of Cancer Neoantigens

TLDR
The most recent advances in research on the immune response to mitochondrial proteins in different cellular conditions are reviewed, including the generation of neoantigens in cancer cells.

Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases

TLDR
Intercellular spontaneous mitochondrial transfer modes, mechanisms, and the latest methods of AMT/T are reviewed, holding great potential for maintaining body homeostasis and regulating pathological processes.

Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function

TLDR
This work presents various examples of TNT-mediated protein transfer in the immune system, cancer microenvironment and in the nervous system, with particular attention to the methods used to verify the transfer of individual proteins.

Exploiting the tumor immune microenvironment and immunometabolism using mitochondria‐targeted drugs: Challenges and opportunities in racial disparity and cancer outcome research

  • B. Kalyanaraman
  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2022
TLDR
Clinical trials should include an appropriate number of Black and Hispanic cancer patients and should validate the intratumoral, antihypoxic effects of MTDs with imaging, to help understand this biological disparity.

Delivery of mitochondria via extracellular vesicles - A new horizon in drug delivery.

  • D. Manickam
  • Biology
    Journal of controlled release : official journal of the Controlled Release Society
  • 2022

References

SHOWING 1-10 OF 36 REFERENCES

Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells

TLDR
The existence of TNTs between co-cultured RT4 and T24 bladder cancer cells is demonstrated and data indicate that TNTs promote intercellular mitochondrial transfer between heterogeneous cells, followed by an increase in the invasiveness of bladder cancer Cells.

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

TLDR
It is concluded that TNT-mediated transfer of functional mitochondria reverse stressed cells in the early stages of apoptosis provides new insights into the survival mechanisms of damaged cells in a multicellular context.

Cutting Edge: Membrane Nanotubes Connect Immune Cells12

TLDR
Evidence is presented that nanotubular highways, or membrane nanotubes, facilitate a novel mechanism for intercellular communication in the immune system, and whether there are physiological functions for nanot tubes is an intriguing new goal for cellular immunology.

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

TLDR
It is proposed that HIV-1 can spread using nanotubular connections formed by short-term intercellular unions in which T cells specialize, and an extracellular matrix scaffold allows T-cell nanotubes to adopt variably shaped contours.

A designer self-assembled supramolecule amplifies macrophage immune responses against aggressive cancer

TLDR
A supramolecular assembly consisting of amphiphiles inhibiting the colony stimulating factor 1 receptor and SIRPα receptors on macrophages significantly enhances antitumour and antimetastatic efficacies in two aggressive animal models of melanoma and breast cancer.

Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages

TLDR
It is shown that HIV-1 promotes TNT formation per se via its protein Nef and a cellular protein M-Sec, which appears to mediate approximately half of viral spread among monocyte-derived macrophages (MDMs).

Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy

TLDR
In a human in vitro system, MSCmiroHi reversed mitochondrial dysfunction in bronchial epithelial cells treated with pro‐inflammatory supernatant of IL‐13‐induced macrophages, and Miro1 overexpression leads to increased stem cell repair.

Physical nanoscale conduit-mediated communication between tumour cells and the endothelium modulates endothelial phenotype

TLDR
A dynamic regulation of the endothelium by cancer cells through the formation of nanoscale intercellular membrane bridges, which act as physical conduits for transfer of microRNAs are reported, leading to the notion of ‘metastatic hijack’.

Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function

TLDR
Gene-expression data revealed that, in NKT cells, glucose is preferentially metabolized by the pentose phosphate pathway and mitochondria, as opposed to being converted into lactate, which indicates that glucose is essential for the effector functions of N KT cells and a high lactate environment is detrimental for NKT cell survival and proliferation.

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

TLDR
It is shown that the mitochondrial gatekeeper pyruvate dehydrogenase (PDH) is a crucial mediator of senescence induced by BRAFV600E, an oncogene commonly mutated in melanoma and other cancers, and a mechanistic relationship between OIS and a key metabolic signalling axis is revealed, which may be exploited therapeutically.