Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells

  title={Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells},
  author={Tanmoy Kumar Saha and Chinmayee Dash and Ruparoshni Jayabalan and Sachin K. Khiste and Arpita Kulkarni and Kiran Kurmi and Jayanta Mondal and Pradip K. Majumder and Aditya Bardia and Hae Lin Jang and Shiladitya Sengupta},
  journal={Nature Nanotechnology},
Cancer progresses by evading the immune system. Elucidating diverse immune evasion strategies is a critical step in the search for next-generation immunotherapies for cancer. Here we report that cancer cells can hijack the mitochondria from immune cells via physical nanotubes. Mitochondria are essential for metabolism and activation of immune cells. By using field-emission scanning electron microscopy, fluorophore-tagged mitochondrial transfer tracing and metabolic quantification, we… 

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