Intercellular junctions: downstream and upstream of Ras?

  • Jaron A Mercer
  • Published 2000 in Seminars in cell & developmental biology


Most human tumors are of epithelial origin, and these tumors gradually lose their epithelial character in a process termed the epithelial-mesenchymal transition. Approximately 40% of human tumors have activating mutations in one of the three RAS genes. Given these statistics, it is critically important to understand the role of Ras signaling in the epithelial-mesenchymal transition. This review considers the mechanisms and effectors through which Ras may regulate intercellular junction formation in epithelial cells. Conversely, intercellular junction proteins themselves may play a role in regulating Ras activation and signaling.


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@article{Mercer2000IntercellularJD, title={Intercellular junctions: downstream and upstream of Ras?}, author={Jaron A Mercer}, journal={Seminars in cell & developmental biology}, year={2000}, volume={11 4}, pages={309-14} }