Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.

  • Shigeo Ohno
  • Published 2001 in Current opinion in cell biology
Two PDZ-domain-containing adapter-like proteins, PAR-3 and PAR-6, and a protein kinase, atypical protein kinase C (PKC), cooperate together to establish cell polarity in a variety of biological contexts. These include asymmetric cell division in early Caenorhabditis elegans embryo and Drosophila neuroblasts, as well as the establishment and maintenance of… (More)