Intercellular junctional proteins as receptors and barriers to virus infection and spread.

Most viruses infect their hosts by crossing the mucosal surfaces of the respiratory, gastrointestinal, or genital tracts, then spread--often through the bloodstream--to other organs; they are shed in bodily secretions to reach new hosts. At each stage in the cycle of infection viruses surmount significant anatomic barriers. This Minireview focuses on the… CONTINUE READING