Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ganciclovir-based gene therapy of human gastrointestinal tumor cells.

@article{Yang1998IntercellularCM,
  title={Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ganciclovir-based gene therapy of human gastrointestinal tumor cells.},
  author={L X Yang and Yawen Chiang and Heinz-Josef Lenz and Kathleen D. Danenberg and Colin Paul Spears and Erlinda M. Gordon and W. French Anderson and Dilip Parekh},
  journal={Human gene therapy},
  year={1998},
  volume={9 5},
  pages={719-28}
}
A bystander effect is described when nontransduced or genetically unmodified cells are killed during death of genetically modified tumor cells transduced with a suicide gene. The "bystander effect" greatly enhances the efficacy of the herpes simplex virus-thymidine kinase/ganciclovir (HSV-TK/GCV) gene therapy approach for cancer. The mechanism of the bystander effect is controversial. In this study, we examined the role of intercellular gap junction communication (GJIC) for the bystander effect… CONTINUE READING
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