Intercellular communication and tissue growth: IX. Junctional membrane structure of hybrids between communication-competent and communication-incompetent cells

@article{Larsen2005IntercellularCA,
  title={Intercellular communication and tissue growth: IX. Junctional membrane structure of hybrids between communication-competent and communication-incompetent cells},
  author={William James Larsen and Roobik Azarnia and Werner R. Loewenstein},
  journal={The Journal of Membrane Biology},
  year={2005},
  volume={34},
  pages={39-54}
}
SummaryThe structure of the membrane junctions of the hybrid cell system, examined in the companion paper in respect to competence for communication through cell-to-cell membrane channels, is here examined by freeze-fracture electron microscopy. The junctions of the channel-competent parent cell and of the channel-competent hybrid cells present aggregates of intramembranous particles typical of “gap junction”; those of the channel-incompetent parent cell and channel-incompetent segregant hybrid… 
12 Citations

Intercellular communication and tissue growth: VIII. A genetic analysis of junctional communication and cancerous growth

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The human genetic factor that corrects the channel defect of the mouse parent cell seems closely linked, if not identical, with that correcting the growth defect, and this genetic correlation encourages the belief that theChannel defect may be an etiological factor in this particular cancer form.

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In comparison with mammalian (or other vertebrate and invertebrate) organized tissues or with insect cell cultures, the mammalian cell cultures are more resistant to junctional blockade, and this difference in transmission stability is discussed in terms of intracellular Ca-buffering capacities of the junctional locales.

Electrical coupling among heart cells in the absence of ultrastructurally defined gap junctions

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Junctions between interstitial cells of the renal medulla: A freeze-fracture study

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It is suggested that the composite junctions observed play a role in the maintainance of the ladder-like arrangement of the interstitial cells in the inner zone in rat, rabbit, hamster and the tree-shrew Tupaia belangeri.

Differences in degree of electrotonic interaction in highly differentiated and reverted cultured heart cell reaggregates

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Two intracellular microelectrodes were used to study electrotonic interaction between cultured embryonic (16- to 20-day-old) chick myocardial cells reaggregated into small spheres in vitro, and two types of functional membrane properties were produced: highly differentiated and reverted reaggRegates.

Electrical interaction of mechanosensitive fibroblasts and myocytes in the heart

TLDR
Novel findings indicate that these processes involve the intercellular transfer of electrical signals between fibroblasts and cardiomyocytes via gap junctions, and the main focus will be on the inter cellular pathways through which fibro Blasts and Cardiomyocyte communicate with each other.

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