Intercellular communication and tissue growth: IX. Junctional membrane structure of hybrids between communication-competent and communication-incompetent cells

@article{Larsen2005IntercellularCA,
  title={Intercellular communication and tissue growth: IX. Junctional membrane structure of hybrids between communication-competent and communication-incompetent cells},
  author={William James Larsen and Roobik Azarnia and Werner R. Loewenstein},
  journal={The Journal of Membrane Biology},
  year={2005},
  volume={34},
  pages={39-54}
}
SummaryThe structure of the membrane junctions of the hybrid cell system, examined in the companion paper in respect to competence for communication through cell-to-cell membrane channels, is here examined by freeze-fracture electron microscopy. The junctions of the channel-competent parent cell and of the channel-competent hybrid cells present aggregates of intramembranous particles typical of “gap junction”; those of the channel-incompetent parent cell and channel-incompetent segregant hybrid… 
12 Citations

Intercellular communication and tissue growth: VIII. A genetic analysis of junctional communication and cancerous growth

The human genetic factor that corrects the channel defect of the mouse parent cell seems closely linked, if not identical, with that correcting the growth defect, and this genetic correlation encourages the belief that theChannel defect may be an etiological factor in this particular cancer form.

Cell junction and cyclic AMP: III. Promotion of junctional membrane permeability and junctional membrane particles in a junction-deficient cell type

The cyclic nucleotide effect on junction was studied in C1-1D cells, a mouse cancer cell type that fails to make permeable junctions in ordinary confluent culture, and a junctional permeability arose in confluent cultures, which on feeding with serum disappeared within two to three days.

Intercellular communication and the control of growth: XII. Alteration of junctional permeability by simian virus 40. roles of the large and smallT antigens

Both antigens are necessary for this junctional alteration—a genetic requirement identical to that for decontrol of growth (but distinct from that of the cytoskeletal alteration).

De novo construction of cell-to-cell channels

The data suggest that the de novo expression of cell-to-cell coupling is accomplished by mRNA-induced protein biosynthesis resulting in the formation of cell to-cell channels.

Experimental depression of junctional membrane permeability in mammalian cell culture. A study with tracer molecules in the 300 to 800 dalton range

In comparison with mammalian (or other vertebrate and invertebrate) organized tissues or with insect cell cultures, the mammalian cell cultures are more resistant to junctional blockade, and this difference in transmission stability is discussed in terms of intracellular Ca-buffering capacities of the junctional locales.

Adrenocortical Gap Junctions and Their Functions

What is known about gap junctions in the adrenal gland is reviewed, with particular attention to their role in adrenocortical cell steroidogenesis and proliferation.

Electrical coupling among heart cells in the absence of ultrastructurally defined gap junctions

It is concluded that organized gap junctions are unnecessary for electrotonic coupling between embryonic heart cells, and support the idea that low-resistance cell-to-cell pathways may exist as isolated channels scattered throughout the area of closely apposed plasma membranes.

Differences in degree of electrotonic interaction in highly differentiated and reverted cultured heart cell reaggregates

Two intracellular microelectrodes were used to study electrotonic interaction between cultured embryonic (16- to 20-day-old) chick myocardial cells reaggregated into small spheres in vitro, and two types of functional membrane properties were produced: highly differentiated and reverted reaggRegates.

Electrical interaction of mechanosensitive fibroblasts and myocytes in the heart

Novel findings indicate that these processes involve the intercellular transfer of electrical signals between fibroblasts and cardiomyocytes via gap junctions, and the main focus will be on the inter cellular pathways through which fibro Blasts and Cardiomyocyte communicate with each other.

CHARACTeRiZATiON OF GAP JUNCTiONS iN THe ADReNAL CORTeX

  • 2016

References

SHOWING 1-10 OF 27 REFERENCES

Intercellular communication and tissue growth: VIII. A genetic analysis of junctional communication and cancerous growth

The human genetic factor that corrects the channel defect of the mouse parent cell seems closely linked, if not identical, with that correcting the growth defect, and this genetic correlation encourages the belief that theChannel defect may be an etiological factor in this particular cancer form.

Gap junctions between electrotonically coupled cells in tissue culture and in brown fat.

An electron microscopic study of replicas of frozen-fractured BHK21 cells and brown fat cells of newborn mice indicates that gap junctions, when they are the only intercellular junctions present, are sufficient to account for electronic coupling between cells.

INTERCELLULAR COMMUNICATION AND TISSUE GROWTH

Three cancer cell strains that fail to make permeable membrane junctions were tested for ability to transfer an endogenous hypoxanthine derivative from cell to cell, and a contact-independent transfer phenomenon was observed with these three cancer cell strain.

Three types of gap junctions interconnecting intestinal epithelial cells visualized by freeze-etching.

  • L. Staehelin
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1972
Using morphological criteria, three different types of gap junctions interlinking adjacent epithelial cells of the small intestine are distinguished, including type-I, type-II and type-III.

Three Types of Gap Junctions Interconnecting Intestinal Epithelial Cells Visualized by Freeze-Etching

Using morphological criteria, it is able to distinguish three different types of gap junctions interlinking adjacent epithelial cells of the small intestine, which may be involved in the control of intercellular flow of differenttypes of regulatory molecules.

INTERCELLULAR COMMUNICATION AND TISSUE GROWTH

SummaryEpithelial cells of normal rat (adult) liver and hamster embryo in tissue culture communicate through membrane junctions: the membrane regions of cell contact are highly ion-permeable.

A FINE STRUCTURAL ANALYSIS OF INTERCELLULAR JUNCTIONS IN THE MOUSE LIVER

Acetone does not cause any detectable change in the structure of the zonula occludens, but the occluding junction becomes leaky to lanthanum following acetone treatment, and the effects of other reagents on the junctions are reported.

Permeability of a cell junction during intracellular injection of divalent cations

Divalent cations are microinjected into Chironomus salivary gland cells while the cell-to-cell passage of fluorescein and electrical coupling are monitored.

HEXAGONAL ARRAY OF SUBUNITS IN INTERCELLULAR JUNCTIONS OF THE MOUSE HEART AND LIVER

A new technique, based on the observations of Doggenweiler and Frenks, has allowed us to demonstrate the presence of similar structures in sections of mouse heart and of mouse liver.

Calcium ion produces graded changes in permeability of membrane channels in cell junction

It is shown that, at low [Ca2+]i elevation, the junctional permeability reduction is indeed selective and that the molecular size limit for junctional channel permeation changes in a graded manner.