Intercellular adhesion molecule-1 inhibits osteogenic differentiation of mesenchymal stem cells and impairs bio-scaffold-mediated bone regeneration in vivo.

@article{Xu2014IntercellularAM,
  title={Intercellular adhesion molecule-1 inhibits osteogenic differentiation of mesenchymal stem cells and impairs bio-scaffold-mediated bone regeneration in vivo.},
  author={Fen-fen Xu and H. A. Zhu and Xi-mei Li and Fei Yang and Ji-de Chen and Bo Tang and Hong-Guang Sun and Y Chu and Rong-xiu Zheng and Yuan-lin Liu and Li-Shing Wang and Yi Irvette Zhang},
  journal={Tissue engineering. Part A},
  year={2014},
  volume={20 19-20},
  pages={2768-82}
}
Mesenchymal stem cell (MSC) loaded bio-scaffold transplantation is a promising therapeutic approach for bone regeneration and repair. However, growing evidence shows that pro-inflammatory mediators from injured tissues suppress osteogenic differentiation and impair bone formation. To improve MSC-based bone regeneration, it is important to understand the mechanism of inflammation mediated osteogenic suppression. In the present study, we found that synovial fluid from rheumatoid arthritis… CONTINUE READING