Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice.

@article{Matsushita2007IntercellularAM,
  title={Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice.},
  author={Yukiyo Matsushita and Minoru Hasegawa and Takashi Matsushita and M Fujimoto and Mayuka Horikawa and Tomoyuki Fujita and Ayako Kawasuji and Fumihide Ogawa and Douglas A. Steeber and Thomas F. Tedder and Kazuhiko Takehara and Shinichi Sato},
  journal={Journal of immunology},
  year={2007},
  volume={179 1},
  pages={698-707}
}
The tight-skin (TSK/+) mouse, a genetic model for systemic sclerosis, develops cutaneous fibrosis. Although a fibrillin 1 gene mutation and immunological abnormalities have been demonstrated, the roles of adhesion molecules have not been investigated. To directly assess roles of adhesion molecules in skin fibrosis, TSK/+ mice lacking L-selectin and/or ICAM-1 were generated. The deficiency of ICAM-1, but not L-selectin, significantly suppressed ( approximately 48%) the development of skin… CONTINUE READING

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