Intercellular adhesion molecule-1 and blood-spinal cord barrier disruption in central nervous system radiation injury.

@article{Nordal2004IntercellularAM,
  title={Intercellular adhesion molecule-1 and blood-spinal cord barrier disruption in central nervous system radiation injury.},
  author={Robert A. Nordal and Carolyn Wong},
  journal={Journal of neuropathology and experimental neurology},
  year={2004},
  volume={63 5},
  pages={474-83}
}
Central nervous system (CNS) injury is a major dose-limiting toxicity that limits the effectiveness of radiation therapy. Blood-brain barrier (BBB) disruption and white matter necrosis are prominent features. Increased expression of intercellular adhesion molecule-1 (ICAM-1) accompanies and is believed to be important in BBB disruption in other CNS injuries. Our aim was to assess the expression of ICAM-1 and its relationship to regions of blood-spinal cord barrier (BSCB) disruption in the… CONTINUE READING
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