Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma.

@article{Wegner1990IntercellularAM,
  title={Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma.},
  author={Craig D. Wegner and Robert H. Gundel and Philip Reilly and N. A. Haynes and L. Gordon Letts and Robert Rothlein},
  journal={Science},
  year={1990},
  volume={247 4941},
  pages={456-9}
}
Airway eosinophilia, epithelial desquamation, and hyperresponsiveness are characteristics of the airway inflammation underlying bronchial asthma. The contribution of intercellular adhesion molecule-1 (ICAM-1) to eosinophil migration and airway responsiveness was studied. ICAM-1 partially mediated eosinophil adhesion to to endothelium in vitro and was upregulated on inflamed bronchial endothelium in vivo. ICAM-1 expression was also upregulated on inflamed airway epithelium in vitro and in vivo… CONTINUE READING

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