Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades.

  title={Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades.},
  author={Andrea K. Hubbard and Robert Rothlein},
  journal={Free radical biology & medicine},
  volume={28 9},
The collective interaction between cells is, in part, mediated by different families of adhesion molecules. Intercellular adhesion molecules (ICAMs) are structurally related members of the immunoglobulin supergene family and are ligands for the beta2 integrin molecules present on leukocytes. Of the five ICAMs identified, ICAM-1 is the most extensively studied. Although ICAM-1 is expressed constitutively at low levels on endothelial cells and on some lymphocytes and monocytes, its expression can… CONTINUE READING
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