Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development.

  title={Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development.},
  author={Hermelijn H Smits and Esther C. de Jong and Joost H. N. Schuitemaker and Theo B. H. Geijtenbeek and Yvette van Kooyk and Martien L. Kapsenberg and Eddy A. Wierenga},
  journal={Journal of immunology},
  volume={168 4},
Th cell polarization toward Th1 or Th2 cells is strongly driven by exogenous cytokines, in particular IL-12 or IL-4, if present during activation by Ag-presenting dendritic cells (DC). However, additional Th cell polarizing mechanisms are induced by the ligation of cell surface molecules on DC and naive Th cells. In the present study, the role of LFA-1/ICAM-1 ligation in human Th cell polarization was investigated. Triggering of LFA-1 on anti-CD3/CD28 stimulated naive Th cells with immobilized… CONTINUE READING


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