Intercellular Delay Regulates the Collective Period of Repressively Coupled Gene Regulatory Oscillator Networks

@article{Wang2014IntercellularDR,
  title={Intercellular Delay Regulates the Collective Period of Repressively Coupled Gene Regulatory Oscillator Networks},
  author={Yongqiang Wang and Yutaka Hori and Shinji Hara and Francis J. Doyle},
  journal={IEEE Transactions on Automatic Control},
  year={2014},
  volume={59},
  pages={211-216}
}
Most biological rhythms are generated by a population of cellular oscillators coupled through intercellular signaling. Recent experimental evidence shows that the collective period may differ significantly from the autonomous period in the presence of intercellular delays. The phenomenon has been investigated using delay-coupled phase oscillators, but the proposed phase model contains no direct biological mechanism, which may weaken the model's reliability in unraveling biophysical principles… CONTINUE READING
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