Intercellular Adhesion Molecule 1 Promotes HIV-1 Attachment but Not Fusion to Target Cells

@inproceedings{Kondo2012IntercellularAM,
  title={Intercellular Adhesion Molecule 1 Promotes HIV-1 Attachment but Not Fusion to Target Cells},
  author={Naoyuki Kondo and Gregory B. Melikyan},
  booktitle={PloS one},
  year={2012}
}
Incorporation of intercellular adhesion molecule 1 (ICAM-1) into HIV-1 particles is known to markedly enhance the virus binding and infection of cells expressing lymphocyte function-associated antigen-1 (LFA-1). At the same time, ICAM-1 has been reported to exert a less pronounced effect on HIV-1 fusion with lymphoid cells. Here we examined the role of ICAM-1/LFA-1 interactions in productive HIV-1 entry into lymphoid cells using a direct virus-cell fusion assay. ICAM-1 promoted HIV-1 attachment… CONTINUE READING
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