Intercalating agents with covalent bond forming capability. A novel type of potential anticancer agents. 2. Derivatives of chrysophanol and emodin.

@article{Koyama1989IntercalatingAW,
  title={Intercalating agents with covalent bond forming capability. A novel type of potential anticancer agents. 2. Derivatives of chrysophanol and emodin.},
  author={Maho Koyama and Kyoko C Takahashi and Ting Chao Chou and Zbigniew Darzynkiewicz and Janusz Kapuściński and Thomas R. Kelly and Kyoichi A. Watanabe},
  journal={Journal of medicinal chemistry},
  year={1989},
  volume={32 7},
  pages={1594-9}
}
Fifty-one new C-methyl-modified derivatives of the anthraquinones chrysophanol and emodin or their various methyl ethers were prepared for structure-activity relationship studies of anticancer activity against mouse leukemia L1210 and human leukemia HL-60 cells. Representative compounds were spectrophotometrically studied for their capacity to interact with natural and denatured DNA. In general, those anthraquinones bearing an amino function interact with DNA. 1,8-Dimethoxyanthraquinones are… CONTINUE READING
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