Intercalated discs: cellular adhesion and signaling in heart health and diseases

@article{Zhao2018IntercalatedDC,
  title={Intercalated discs: cellular adhesion and signaling in heart health and diseases},
  author={Guangze Zhao and Ye Qiu and Huifang M. Zhang and Decheng Yang},
  journal={Heart Failure Reviews},
  year={2018},
  volume={24},
  pages={115-132}
}
Intercalated discs (ICDs) are highly orchestrated structures that connect neighboring cardiomyocytes in the heart. Three major complexes are distinguished in ICD: desmosome, adherens junction (AJ), and gap junction (GJ). Desmosomes are major cell adhesion junctions that anchor cell membrane to the intermediate filament network; AJs connect the actin cytoskeleton of adjacent cells; and gap junctions metabolically and electrically connect the cytoplasm of adjacent cardiomyocytes. All these… Expand
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References

SHOWING 1-10 OF 215 REFERENCES
Intercalated Discs and Arrhythmogenic Cardiomyopathy
TLDR
This review highlights recent advances in understanding the link between ID alterations and the molecular genetics and pathogenesis of arrhythmogenic right ventricular cardiomyopathy (ARVC). Expand
Refining the molecular organization of the cardiac intercalated disc
TLDR
An extensively integrated model of the cardiac intercalated disc (ID), a highly orchestrated structure that connects adjacent cardiomyocytes, is presented, illustrating the interdependencies of ID proteins. Expand
Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts
TLDR
Clusters are grouped into clusters that demonstrate functionally interactive groups of proteins demonstrating that ICDs play a key role in cardiomyocyte function. Expand
Cell-cell connection to cardiac disease.
TLDR
This review will discuss recent scientific developments related to the ICD and focus on its role in regulating cardiac muscle structure, signaling, and disease. Expand
Xin proteins and intercalated disc maturation, signaling and diseases.
TLDR
What is known about Xin repeat-containing proteins and how this protein family promotes ICD maturation and stability for normal cardiac function is reviewed to discuss recent advances in the anatomy and function of ICDs. Expand
N-Cadherin/Catenin Complex as a Master Regulator of Intercalated Disc Function
TLDR
This review summarizes recent progress in understanding the in vivo function(s) of AJ components in cardiac homeostasis and disease and indicates that AJ and Des components are capable of mixing together resulting in a “hybrid adhering junction” or “area composita". Expand
Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion
TLDR
Positive adhesiotropy is shown as a new cardiac function of sympathetic signaling dependent on Pg phosphorylation at S665 by protein kinase A, and this mechanism may be of high medical relevance because loss of junctional Pg is a hallmark of arrhythmogenic cardiomyopathy. Expand
The Cardiac Desmosome and Arrhythmogenic Cardiomyopathies: From Gene to Disease
TLDR
The cellular and molecular biology of the desmosome, current knowledge on the relation of desmosomal mutations and disease phenotypes, and an overview of the molecular pathophysiology of arrhythmogenic right ventricular cardiomyopathy are presented. Expand
Cardiac-Myocyte-Specific Excision of the Vinculin Gene Disrupts Cellular Junctions, Causing Sudden Death or Dilated Cardiomyopathy
TLDR
This is the first report of tissue-specific inactivation of the Vcl gene and shows that it is required for preservation of normal cell-cell and cell-matrix adhesive structures. Expand
Induced Deletion of the N-Cadherin Gene in the Heart Leads to Dissolution of the Intercalated Disc Structure
TLDR
This animal model provides the first demonstration of the hierarchical relationship of the structural components of the intercalated disc in the working myocardium, thus establishing N-cadherin’s paramount importance in maintaining the structural integrity of the heart. Expand
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