Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility

  title={Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility},
  author={Petr Flachs and Ondřej Mihola and Petr Simecek and Soňa Gregorov{\'a} and John C. Schimenti and Yasuhisa Matsui and Fr{\'e}d{\'e}ric Baudat and Bernard de Massy and Jaroslav Pi{\'a}lek and Jir{\'i} Forejt and Zdenek Trachtulec},
  booktitle={PLoS genetics},
The Dobzhansky-Muller model of incompatibilities explains reproductive isolation between species by incorrect epistatic interactions. Although the mechanisms of speciation are of great interest, no incompatibility has been characterized at the gene level in mammals. The Hybrid sterility 1 gene (Hst1) participates in the arrest of meiosis in F(1) males of certain strains from two Mus musculus subspecies, e.g., PWD from M. m. musculus and C57BL/6J (henceforth B6) from M. m. domesticus. Hst1 has… CONTINUE READING
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Hybrid male sterility genes in the mouse subspecific crosses

  • J Forejt, J Pialek, Z Trachtulec
  • 2012
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