Interactive toxicity of chlorpyrifos and parathion in neonatal rats: role of esterases in exposure sequence-dependent toxicity.

@article{Kacham2006InteractiveTO,
  title={Interactive toxicity of chlorpyrifos and parathion in neonatal rats: role of esterases in exposure sequence-dependent toxicity.},
  author={R Kacham and Siddharth Karanth and Praveena Baireddy and Jing ai Liu and Carey Pope},
  journal={Toxicology and applied pharmacology},
  year={2006},
  volume={210 1-2},
  pages={142-9}
}
We previously reported that sequence of exposure to chlorpyrifos and parathion in adult rats can markedly influence toxic outcome. In the present study, we evaluated the interactive toxicity of chlorpyrifos (8 mg/kg, po) and parathion (0.5 mg/kg, po) in neonatal (7 days old) rats. Rats were exposed to the insecticides either concurrently or sequentially (separated by 4 h) and sacrificed at 4, 8, and 24 h after the first exposure for biochemical measurements (cholinesterase activity in brain… CONTINUE READING