Interactive regulation by the Bacillus subtilis global regulators CodY and ScoC.

  title={Interactive regulation by the Bacillus subtilis global regulators CodY and ScoC.},
  author={Boris R. Belitsky and Giulia Barbieri and Alessandra M. Albertini and Eugenio Ferrari and Mark A. Strauch and Abraham L. Sonenshein},
  journal={Molecular microbiology},
  volume={97 4},
CodY and ScoC are Bacillus subtilis transcriptional regulators that control the expression of dozens of genes and operons. Using scoC-lacZ fusions and DNA-binding experiments, we show here that scoC is directly repressed by CodY. This effect creates multiple forms of cascade regulation. For instance, expression of the dtpT gene, which is directly and negatively controlled by ScoC and encodes a putative oligopeptide permease, was activated indirectly by CodY due to CodY-mediated repression of… CONTINUE READING
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