Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat.

@article{Delafoy2006InteractiveIO,
  title={Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat.},
  author={Laure Delafoy and Agathe Gelot and Denis Ardid and Alain Eschalier and Chantal Bertrand and Annette M. Doherty and Laurent Diop},
  journal={Gut},
  year={2006},
  volume={55 7},
  pages={940-5}
}
BACKGROUND AND AIMS Neutrophins are involved in somatic and visceral hypersensitivity. The action of nerve growth factor (NGF) on sensory neurones contributes to the development of referred colonic hypersensitivity induced by trinitrobenzene sulfonic acid (TNBS). Based on data on brain derived neurotrophic factor (BDNF) and calcitonin gene related peptide (CGRP) in pain, the aims of the present study were: (1) to investigate the involvement of BDNF and CGRP in this model of referred colonic… CONTINUE READING