Interactive influences of peroxisome proliferator-activated receptor α activation and glucocorticoids on pancreatic beta cell compensation in insulin resistance induced by dietary saturated fat in the rat

@article{Holness2005InteractiveIO,
  title={Interactive influences of peroxisome proliferator-activated receptor α activation and glucocorticoids on pancreatic beta cell compensation in insulin resistance induced by dietary saturated fat in the rat},
  author={Mark J. Holness and Nicholas D Smith and Gemma K. Greenwood and Mary C. Sugden},
  journal={Diabetologia},
  year={2005},
  volume={48},
  pages={2062-2068}
}
We sought to elucidate whether excess glucocorticoids and increased dietary lipids act synergistically to impair glucose tolerance and, if so, whether activation of peroxisome proliferator-activated receptor α (PPARα) has an adverse or beneficial effect on glucose tolerance. Dexamethasone (100 μg kg−1 body weight day−1; 5 days) was administered to insulin-resistant rats fed a high-saturated-fat (HF) diet for 4weeks. The PPARα agonist WY14643 was administered (50 mg kg−1 body weight… CONTINUE READING