Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease.

@article{Schmidt2003InteractiveEO,
  title={Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease.},
  author={Michael A. Schmidt and Anjan K. Chakrabarti and Chris Kehrer and Dana Pfeninnger and Robert D. Brook and N Kaciroti and Claire Duvernoy and Anthony A. Killeen and Sanjay Rajagopalan},
  journal={Vascular medicine},
  year={2003},
  volume={8 3},
  pages={177-83}
}
The products of nitric oxide synthase (NOS) and angiotensin-converting enzyme (ACE) play a critical role in determining vessel wall structure and function. Polymorphisms in both genes have been independently demonstrated to influence propensity to cardiovascular events. The purpose of this study was to determine the influence of the homozygous G849T (Glu298-->Asp) polymorphism in NOS III on peripheral conduit artery endothelial function and to elucidate the modifier role, if any, of a common… CONTINUE READING