Interactive effects of paraoxon and pyridostigmine on blood-brain barrier integrity and cholinergic toxicity.

@article{Song2004InteractiveEO,
  title={Interactive effects of paraoxon and pyridostigmine on blood-brain barrier integrity and cholinergic toxicity.},
  author={Xun Song and Carey Pope and Ramesh K Murthy and Jamaluddin Shaikh and Bachchu Lal and Joseph P. Bressler},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={78 2},
  pages={241-7}
}
The effect of the organophosphorous insecticide paraoxon on the integrity of the blood-brain barrier (BBB) and permeability of pyridostigmine (PYR), a peripheral inhibitor of cholinesterase activity, was examined in Long Evans rats. The integrity of the BBB was examined by measuring the number of capillaries leaking horseradish peroxidase, which was… CONTINUE READING