Interactive effects of mechanical stretching and extracellular matrix proteins on initiating osteogenic differentiation of human mesenchymal stem cells.

@article{Huang2009InteractiveEO,
  title={Interactive effects of mechanical stretching and extracellular matrix proteins on initiating osteogenic differentiation of human mesenchymal stem cells.},
  author={Chien-Hsun Huang and M Chen and T G Young and J G Jeng and Yi-Jane Chen},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={108 6},
  pages={1263-73}
}
Human mesenchymal stem cells (hMSCs) are characterized by their abilities to differentiate into different lineages, including osteoblasts. Besides soluble factors, mechanical strain and extracellular matrix (ECM) proteins play important roles in osteogenic differentiation of hMSCs. However, interactions between them are still not fully understood. The purpose of this study was to investigate the combined effects of insoluble chemical and mechanical factors (ECM proteins vs. cyclic stretching… CONTINUE READING