Interactive effects of excitotoxic injury and dietary restriction on microgliosis and neurogenesis in the hippocampus of adult mice

@article{Lee2003InteractiveEO,
  title={Interactive effects of excitotoxic injury and dietary restriction on microgliosis and neurogenesis in the hippocampus of adult mice},
  author={Jaewon Lee and Wendy W. Auyeung and Mark P. Mattson},
  journal={NeuroMolecular Medicine},
  year={2003},
  volume={4},
  pages={179-195}
}
Responses to neuronal degeneration are complex, involving activation of microglia, astrocytes, and synaptic remodeling. It has also been suggested that neuronal injury stimulates neurogenesis, the production of new neurons from neural stem cells. Because dietary restriction (DR) can increase hippocampal neurogenesis and promotes the survival of neurons following injury, we determined the effects of DR on the responses of neural stem cells, microglia, and astrocytes in the hippocampus to seizure… CONTINUE READING

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