Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan.

@article{Chang2009InteractiveEO,
  title={Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan.},
  author={Chin-Hao Chang and Chin-Fu Hsiao and G. -t. Chang and Y B Tsai and Yuh-Min Chen and M W Huang and W Su and Wan-Shan Hsieh and Pan-Chyr Yang and C. -J. Chen and Chao A. Hsiung},
  journal={American journal of epidemiology},
  year={2009},
  volume={170 6},
  pages={695-702}
}
Human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) plays an important role in repairing oxidative DNA damage induced by tobacco carcinogens. In this case-control study, the authors examined the interactive effect of hOGG1 gene polymorphisms and cigarette smoking on the risk of lung cancer in Taiwan. A total of 1,096 cases and 1,007 controls were enrolled from 6 medical centers in Taiwan during 2002-2004. hOGG1 Ser326Cys genetic polymorphisms were determined using the MassARRAY system (SEQUENOM, Inc… CONTINUE READING

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