Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus.

@article{Wang2000InteractionsWC,
  title={Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus.},
  author={Gelin Wang and Kazuhito Amanai and Bing Wang and Jin Jiang},
  journal={Genes & development},
  year={2000},
  volume={14 22},
  pages={2893-905}
}
The Hedgehog (Hh) family of secreted proteins controls many aspects of growth and patterning in animal development. In Drosophila, Hh acts by preventing the formation of a truncated repressor form of Cubitus interruptus (Ci) and stimulating the transcriptional activity of full-length Ci. Here, we provide evidence that Costal2 (Cos2) and Suppressor of Fused [Su(fu)] inhibit Ci by tethering it in the cytoplasm, whereas Hh induces nuclear translocaltion of Ci through Fused (Fu). We have identified… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 88 extracted citations

Smoothened regulation in response to Hedgehog stimulation

Frontiers in Biology • 2015
View 5 Excerpts
Highly Influenced

Hedgehog signaling and gastrointestinal cancer.

Biochimica et biophysica acta • 2010
View 9 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…