Interactions via intrinsically disordered regions: what kind of motifs?

  title={Interactions via intrinsically disordered regions: what kind of motifs?},
  author={Rita Pancsa and M{\'o}nika Fuxreiter},
  journal={IUBMB life},
  volume={64 6},
Proteins containing intrinsically disordered (ID) regions are widespread in eukaryotic organisms and are mostly utilized in regulatory processes. ID regions can mediate binary interactions of proteins or promote organization of large assemblies. Post-translational modifications of ID regions often serve as decision points in signaling pathways. Why Nature distinguished ID proteins in molecular recognition functions? In a simple view, binding of ID regions is accompanied by a large entropic… CONTINUE READING


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