Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function

@article{Getty2010InteractionsOT,
  title={Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function},
  author={Amanda L. Getty and David A. Pearce},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={68},
  pages={453-474}
}
Neuronal ceroid lipofuscinoses (NCL) are caused by mutations in eight different genes, are characterized by lysosomal accumulation of autofluorescent storage material, and result in a disease that causes degeneration of the central nervous system (CNS). Although functions are defined for some of the soluble proteins that are defective in NCL (cathepsin D, PPT1, and TPP1), the primary function of the other proteins defective in NCLs (CLN3, CLN5, CLN6, CLN7, and CLN8) remain poorly defined… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 216 references

Similar Papers

Loading similar papers…