Interactions of the natural product kendomycin and the 20S proteasome.

Abstract

Natural products are a valuable source for novel lead structures in drug discovery, but for the majority of isolated bioactive compounds, the cellular targets are unknown. The structurally unique ansa-polyketide kendomycin (KM) was reported to exert its potent cytotoxic effects via impairment of the ubiquitin proteasome system, but the exact mode of action… (More)
DOI: 10.1016/j.jmb.2014.06.019

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