Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor.

@article{Naddeo2005InteractionsOT,
  title={Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor.},
  author={Mariarosaria Naddeo and Luigi Vitagliano and Aniello Russo and Giovanni Gotte and G D'alessio and Salvatore Sorrentino},
  journal={FEBS letters},
  year={2005},
  volume={579 12},
  pages={2663-8}
}
Ribonuclease A (RNase A) dimers have been recently found to be endowed with some of the special, i.e., non-catalytic biological activities of RNases, such as antitumor and aspermatogenic activities. These activities have been so far attributed to RNases which can escape the neutralizing action of the cytosolic RNase inhibitor (cRI). However, when the interactions of the two cytotoxic RNase A dimers with cRI were investigated in a quantitative fashion and at the molecular level, the dimers were… CONTINUE READING