Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules

@article{Milev1994InteractionsOT,
  title={Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules},
  author={Peter Milev and David Raul Friedlander and Takeshi Sakurai and L Karthikeyan and Manuela Flad and Ren{\'e}e K. Margolis and Martin Grumet and Richard U. Margolis},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={127},
  pages={1703 - 1715}
}
Phosphacan is a chondroitin sulfate proteoglycan produced by glial cells in the central nervous system, and represents the extracellular domain of a receptor-type protein tyrosine phosphatase (RPTP zeta/beta). We previously demonstrated that soluble phosphacan inhibited the aggregation of microbeads coated with N-CAM or Ng-CAM, and have now found that soluble 125I-phosphacan bound reversibly to these neural cell adhesion molecules, but not to a number of other cell surface and extracellular… CONTINUE READING

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DSD-1-proteoglycan is the mouse homolog of phosphacan and displays opposing effects on neurite outgrowth dependent on neuronal lineage.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
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The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
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