Interactions of the aryl hydrocarbon receptor with inflammatory mediators: beyond CYP1A regulation.

@article{Vondrek2011InteractionsOT,
  title={Interactions of the aryl hydrocarbon receptor with inflammatory mediators: beyond CYP1A regulation.},
  author={Jan Vondr{\'a}{\vc}ek and Lenka Umannov{\'a} and Miroslav Machala},
  journal={Current drug metabolism},
  year={2011},
  volume={12 2},
  pages={
          89-103
        }
}
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which plays a major role in toxic effects of environmental pollutants. It is a pivotal regulator of several xenobiotic-metabolizing enzymes (XMEs), and is now considered to play an important role also in control of cell cycle, apoptosis and cell differentiation. The accumulating evidence suggests that there exists a multiple crosstalk between AhR activation and the signaling pathways activated by inflammatory… CONTINUE READING

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