Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant alpha-lipoic acid on insulin resistance in the obese Zucker rat.

@article{Muellenbach2008InteractionsOT,
  title={Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant alpha-lipoic acid on insulin resistance in the obese Zucker rat.},
  author={Elizabeth A Muellenbach and Cody J. Diehl and Mary K. Teachey and Katherine A Lindborg and Tara L Archuleta and Nicholas B Harrell and Gaby Andersen and Veronika Somoza and Oliver Hasselwander and Markus Matuschek and Erik J. Henriksen},
  journal={Metabolism: clinical and experimental},
  year={2008},
  volume={57 10},
  pages={1465-72}
}
Oxidative stress and protein glycation can contribute to the development of insulin resistance and complications associated with type 2 diabetes mellitus. The antioxidant alpha-lipoic acid (ALA) reduces oxidative stress and the formation of advanced glycation end products (AGEs) and improves insulin sensitivity in skeletal muscle and liver. The AGE… CONTINUE READING