Interactions of the C Terminus of Metabotropic Glutamate Receptor Type 1α with Rat Brain Proteins

  title={Interactions of the C Terminus of Metabotropic Glutamate Receptor Type 1$\alpha$ with Rat Brain Proteins},
  author={Francisco Ciruela and Melanie J. Robbins and Antony C. Willis and R. A. J. Mcilhinney},
  journal={Journal of Neurochemistry},
Abstract : Metabotropic glutamate receptors (mGluRs) are coupled to G protein second messenger pathways and modulate glutamate neurotransmission in the brain, where they are targeted to specific synaptic locations. As part of a strategy for defining the mechanisms for the specific targeting of mGluR1 α, rat brain proteins which interact with the intracellular carboxy terminus of mGluR1 α have been characterized, using affinity chromatography on a glutathione S‐transferase fusion protein that… 
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