Interactions of synapsin I with phospholipids: possible role in synaptic vesicle clustering and in the maintenance of bilayer structures

@article{Benfenati1993InteractionsOS,
  title={Interactions of synapsin I with phospholipids: possible role in synaptic vesicle clustering and in the maintenance of bilayer structures},
  author={Fabio Benfenati and Flavia Valtorta and Maria Cristina Rossi and Franco Onofri and Talvinder S. Sihra and Paul Greengard},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={123},
  pages={1845 - 1855}
}
Synapsin I is a synaptic vesicle-specific phosphoprotein composed of a globular and hydrophobic head and of a proline-rich, elongated and basic tail. Synapsin I binds with high affinity to phospholipid and protein components of synaptic vesicles. The head region of the protein has a very high surface activity, strongly interacts with acidic phospholipids and penetrates the hydrophobic core of the vesicle membrane. In the present paper, we have investigated the possible functional effects of the… CONTINUE READING