Interactions of synapsin I with phospholipids: possible role in synaptic vesicle clustering and in the maintenance of bilayer structures

@article{Benfenati1993InteractionsOS,
  title={Interactions of synapsin I with phospholipids: possible role in synaptic vesicle clustering and in the maintenance of bilayer structures},
  author={Fabio Benfenati and Flavia Valtorta and Maria Cristina Rossi and Franco Onofri and Talvinder S. Sihra and Paul Greengard},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={123},
  pages={1845 - 1855}
}
Synapsin I is a synaptic vesicle-specific phosphoprotein composed of a globular and hydrophobic head and of a proline-rich, elongated and basic tail. Synapsin I binds with high affinity to phospholipid and protein components of synaptic vesicles. The head region of the protein has a very high surface activity, strongly interacts with acidic phospholipids and penetrates the hydrophobic core of the vesicle membrane. In the present paper, we have investigated the possible functional effects of the… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 69 references

Synaptie vesicle pbosphoproteins and regulation of synaptic function

  • S. L. Cochran, L. J. Greenfield, D. C. Brosius, T. Ueda
  • Science ( wash . DC ) .
  • 1993

Effects of temperature variation and phenethyl alcohol addition on acyl chain order and lipid organization in Escherichia coli derived membrane systems . A 3 Hand 3 mp - NMR study

  • A. K. Hall, A. Weinstein L, T. S. Reese
  • Biochim . Biophys . Acta .
  • 1992

Synap - sin I regulates glutamate release from rat brain synaptosomes

  • S. Nir, J. Wilschut, J. Bentz
  • J . Neurochem .
  • 1992

The annexins and exocytosis

  • M. J. Hope
  • Science ( Wash . DC ) .
  • 1992

Computer modeling of synapsin I binding to synaptic vesicles and F - aetin : implications for regulation of neurotransmitter release

  • F. Benfenati, F. Valtorta, E. Chieregatti, P. Greengard
  • Proc . Natl . Acad . Sci . USA .
  • 1991

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