Interactions of sildenafil with various coronary vasodilators in isolated porcine coronary artery.

@article{Sakuma2002InteractionsOS,
  title={Interactions of sildenafil with various coronary vasodilators in isolated porcine coronary artery.},
  author={Ichiro Sakuma and Yasuhiro Akaishi and Hiroshi Tomioka and Atsushi Sato and Akira Kitabatake and Yuichi Hattori},
  journal={European journal of pharmacology},
  year={2002},
  volume={437 3},
  pages={155-63}
}
There are reports of serious hypotension or circulatory shock when sildenafil citrate, a selective cyclic nucleotide phosphodiesterase type 5 inhibitor, which was developed for the treatment of erectile dysfunction, is given to patients taking certain coronary vasodilators. We thus examined the interaction of sildenafil with various coronary vasodilators including nitric oxide (NO) donors in isolated porcine coronary artery. Sildenafil caused concentration-dependent relaxations of the artery… CONTINUE READING

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