Interactions of sex hormone-binding globulin with target cells

@article{Rosner2010InteractionsOS,
  title={Interactions of sex hormone-binding globulin with target cells},
  author={William Rosner and Daniel J. Hryb and Scott M. Kahn and Atif M. Nakhla and Nicholas A. Romas},
  journal={Molecular and Cellular Endocrinology},
  year={2010},
  volume={316},
  pages={79-85}
}

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References

SHOWING 1-10 OF 70 REFERENCES
[Interaction of blood sex steroid-binding globulin with cell membranes of human decidual tissue].
TLDR
It was shown that SHBG complexed with estradiol specifically interacts with these membranes; such serum globulins as albumin, orosomucoid, transferrin, transcortin and the thyroxine-binding globulin do not compete with SHBG for the binding sites on the membranes.
Sex Hormone-binding Globulin in the Human Prostate Is Locally Synthesized and May Act as an Autocrine/Paracrine Effector*
TLDR
It is demonstrated that SHBG is produced in human prostate cancer cell lines as well as in cultured human prostate epithelial and stromal cells, consistent with the hypothesis thatSHBG, destined to participate in signaling at the cell membrane, is locally regulated and produced.
Prostatic distribution of sex hormone-binding globulin and cortisol-binding globulin in benign hyperplasia.
TLDR
Epithelial tissue was separated from stroma and found not to contain the SHBG- or CBG-like proteins, however, substantial amounts of these proteins remained associated with the stroma, suggesting that they may be constituents of interstitial fluid in this tissue compartment.
The hepatic receptor for sex steroid-binding protein: study on a non-malignant cell line (Chang liver).
TLDR
SBP was shows to recognize two binding sites with different affinities; the low affinity site was shown to possess a remarkably high capacity, which could be related to the unique role of the liver with regard to both SBP and sex steroids.
Receptors for androgen-binding proteins: Internalization and intracellular signalling
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