Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor

  title={Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor},
  author={E. -P. P{\"a}lvim{\"a}ki and Hannu Majasuo and Aki Laakso and Mikko Kuoppam{\"a}ki and E. K. G. Syv{\"a}lahti and Bryan L. Roth and Jarmo Hietala},
Interactions of the selective serotonin reuptake inhibitors (SSRIs) citalopram, fluoxetine and its main metabolite norfluoxetine, and the tricyclic anti-depressant (TCA) imipramine with the rat serotonin 5-HT2C receptor in a clonal cell line and in the rat choroid plexus were investigated by radioligand binding and phosphoinositide (PI) hydrolysis assays. For comparison, the affinities of a variety of other antidepressants of different chemical classes for the cloned rat 5-HT2C and 5-HT2A… 

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