Interactions of recombinant human histamine H1, H2, H3, and H4 receptors with 34 antidepressants and antipsychotics

@article{Appl2011InteractionsOR,
  title={Interactions of recombinant human histamine H1, H2, H3, and H4 receptors with 34 antidepressants and antipsychotics},
  author={Heidrun Appl and Tobias Holzammer and Stefan Dove and Ekkehard Haen and Andrea Strasser and Roland Seifert},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2011},
  volume={385},
  pages={145-170}
}
Antidepressants and antipsychotics affect multiple molecular targets. Consequently, these drugs exhibit not only unique profiles of therapeutic effects but also several undesired effects. Histamine receptors (H1R, H2R, H3R, and H4R) belong to the large family of G protein-coupled receptors and are very important drug targets. All four HxR subtypes are expressed in the CNS. Interactions of lipophilic, blood–brain barrier-penetrating drugs with HxRs could contribute to therapeutic and unwanted… Expand
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