Interactions of putative heparin-binding domains of basic fibroblast growth factor and its receptor, FGFR-1, with heparin using synthetic peptides

@article{Kinsella1998InteractionsOP,
  title={Interactions of putative heparin-binding domains of basic fibroblast growth factor and its receptor, FGFR-1, with heparin using synthetic peptides},
  author={Lisa Kinsella and Hai-lan Chen and John Alexander Smith and Philip Spencer Rudland and David G Fernig},
  journal={Glycoconjugate Journal},
  year={1998},
  volume={15},
  pages={419-422}
}
We have examined structure-function relationships that have been proposed to account for the heparin-binding properties of basic fibroblast growth factor and its receptor, FGFR-1, using synthetic peptides, DNA synthesis assays and binding assays in a resonant mirror biosensor. The results suggest that the interaction of FGFR-1 with heparin may not be physiologically relevant and that the site of interaction of the polysaccharide on bFGF is more complex than has been anticipated. © 1998 Rapid… CONTINUE READING