Interactions of platinum complexes, peptides, methionine and dehydrogenases.

@article{Melius1977InteractionsOP,
  title={Interactions of platinum complexes, peptides, methionine and dehydrogenases.},
  author={P. Melius and C. A. Mcauliffe and I. Photaki and M. Sakarellou-Daitsiotou},
  journal={Bioinorganic chemistry},
  year={1977},
  volume={7 3},
  pages={
          203-10
        }
}
  • P. Melius, C. A. Mcauliffe, +1 author M. Sakarellou-Daitsiotou
  • Published 1977
  • Chemistry, Medicine
  • Bioinorganic chemistry
  • Eight platinum-methionine complexes have been investigated as inhibitors of the alcohol (EC 1.1.1.1) and lactate (EC 1.1.1.27) dehydrogenase systems. While only one complex, Pt(Met)Cl2, had two halogen ligands on the platinum, all the complexes were able to inhibit both enzyme systems. Of the various methionine and histidine containing peptides evaluated, the dipeptide Met-Met gave the best protection against inhibition by N-alkyl-substituted ethylenediamine-platinum complexes. The histidine… CONTINUE READING
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