Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation.

@article{Kim2009InteractionsOP,
  title={Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation.},
  author={Chungho Kim and Tong-Lay Lau and Tobias S Ulmer and Mark H Ginsberg},
  journal={Blood},
  year={2009},
  volume={113 19},
  pages={4747-53}
}
Clustering and occupancy of platelet integrin alpha(IIb)beta(3) (GPIIb-IIIa) generate biologically important signals: conversely, intracellular signals increase the integrins' affinity, leading to integrin activation; both forms of integrin signaling play important roles in hemostasis and thrombosis. Indirect evidence implicates interactions between integrin alpha and beta transmembrane domains (TMDs) and cytoplasmic domains in integrin signaling; however, efforts to directly identify these… CONTINUE READING

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Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation . Clustering and occupancy of platelet integrin alpha(IIb)beta(3 )
Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation . Clustering and occupancy of platelet integrin alpha(IIb)beta(3 )
Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation . Clustering and occupancy of platelet integrin alpha(IIb)beta(3 )
Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation . Clustering and occupancy of platelet integrin alpha(IIb)beta(3 )
( GPIIb - IIIa ) generate biologically important signals : conversely , intracellular signals increase the integrins ' affinity , leading to integrin activation ; both forms of integrin signaling play important roles in hemostasis and thrombosis .
( GPIIb - IIIa ) generate biologically important signals : conversely , intracellular signals increase the integrins ' affinity , leading to integrin activation ; both forms of integrin signaling play important roles in hemostasis and thrombosis .
( GPIIb - IIIa ) generate biologically important signals : conversely , intracellular signals increase the integrins ' affinity , leading to integrin activation ; both forms of integrin signaling play important roles in hemostasis and thrombosis .
( GPIIb - IIIa ) generate biologically important signals : conversely , intracellular signals increase the integrins ' affinity , leading to integrin activation ; both forms of integrin signaling play important roles in hemostasis and thrombosis .
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