Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions

@inproceedings{Bastian2013InteractionsOP,
  title={Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions},
  author={Arangassery Rosemary Bastian and Mark R Contarino and Lauren D. Bailey and Rachna Aneja and Diogo Rodrigo de Magalh{\~a}es Moreira and Kevin J. Freedman and Karyn McFadden and Caitlin Duffy and Ali Emileh and George J Leslie and Jeffrey M. Jacobson and James A Hoxie and Irwin M. Chaiken},
  booktitle={Retrovirology},
  year={2013}
}
We examined the underlying mechanism of action of the peptide triazole thiol, KR13 that has been shown previously to specifically bind gp120, block cell receptor site interactions and potently inhibit HIV-1 infectivity. KR13, the sulfhydryl blocked KR13b and its parent non-sulfhydryl peptide triazole, HNG156, induced gp120 shedding but only KR13 induced p24… CONTINUE READING