Interactions of paralytic shellfish toxins with xenobiotic-metabolizing and antioxidant enzymes in rodents.

@article{Hong2003InteractionsOP,
  title={Interactions of paralytic shellfish toxins with xenobiotic-metabolizing and antioxidant enzymes in rodents.},
  author={Hai-zheng Hong and Paul K S Lam and Dennis P. H. Hsieh},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2003},
  volume={42 4},
  pages={425-31}
}
Paralytic shellfish toxins (PSTs) are neurotoxins known to block voltage-gated sodium channels in intoxicated animals and humans. Their metabolism in mammalian systems and their effects on other receptors are not as well understood. In this study, we investigated the in vitro metabolism of two classes of PSTs, gonyautoxin 2/3 (GTX2/3) and C1/2 toxins (C1/2), using rat and mouse liver enzyme preparations. We also analyzed the effects of these toxins on several antioxidant and xenobiotic… CONTINUE READING