Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.

@article{Loga1975InteractionsOO,
  title={Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.},
  author={Slobodan Loga and Susan D Curry and Malcolm H. Lader},
  journal={British journal of clinical pharmacology},
  year={1975},
  volume={2 3},
  pages={197-208}
}
1 Two studies were carried out on acutely psychotic patients receiving chlorpromazine (100 mg) 8-hourly. 2 In the pilot study on five patients, plasma chlorpromazine concentrations fell over the course of 3 weeks of treatment and parallel changes were noted in the plasma half-life of antipyrine, salivation rate and handwriting length. 3 In the main study involving twelve patients treated for 15 weeks, the above findings were confirmed and were interpreted as indicating that chlorpromazine… CONTINUE READING