Interactions of opioids with caffeine: evaluation by ambulatory activity in mice.

@article{Kuribara1994InteractionsOO,
  title={Interactions of opioids with caffeine: evaluation by ambulatory activity in mice.},
  author={Hisashi Kuribara and Yoshitaka Uchihashi},
  journal={The Journal of pharmacy and pharmacology},
  year={1994},
  volume={46 2},
  pages={
          141-4
        }
}
  • Hisashi Kuribara, Yoshitaka Uchihashi
  • Published 1994
  • Medicine, Chemistry
  • The Journal of pharmacy and pharmacology
  • Morphine (up to 10 mg kg-1), buprenorphine (up to 0.1 mg kg-1), pentazocine (30 mg kg-1) and caffeine (up to 10 mg kg-1), significantly increased mouse ambulation. The combination of morphine, buprenorphine and pentazocine with caffeine generally enhanced the effect. Dopamine D1- and D2-receptor bockade, depletion of stored dopamine, and inhibition of dopamine synthesis could reduce the ambulation increased by single administration of morphine, buprenorphine and caffeine, and by combined… CONTINUE READING

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