Interactions of naloxone with morphine, amphetamine and phencyclidine on fixed interval responding for intracranial self-stimulation in rats

@article{Schaefer1990InteractionsON,
  title={Interactions of naloxone with morphine, amphetamine and phencyclidine on fixed interval responding for intracranial self-stimulation in rats},
  author={Gerald J. Schaefer and Richard P. Michael},
  journal={Psychopharmacology},
  year={1990},
  volume={102},
  pages={263-268}
}
Rats were implanted with stimulating electrodes aimed at the medial forebrain bundle-lateral hypothalamus (MFB-LH) and were trained to lever-press for brain self-stimulation on a fixed interval: 60 s schedule of reinforcement. The effects of graded doses of naloxone (0.1–30 mg/kg), morphine (0.3–5.6 mg/kg), naloxone plus morphine,d-amphetamine (0.03–1.0 mg/kg), naloxone plusd-amphetamine, phencyclidine (0.3–5.6 mg/kg), and naloxone plus phencyclidine were tested. Naloxone produced a significant… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Animal Models of Drug Addiction

  • Neuromethods
  • 2011
VIEW 2 EXCERPTS
CITES BACKGROUND & METHODS

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

Effects of acute and chronic administration of phencyclidine on the A10 dopaminergic mesolimbic system: electrophysiological and behavioral correlates

ED French
  • Neuropharmacology
  • 1988