Interactions of liposomes with the reticuloendothelial system. Effects of reticuloendothelial blockade on the clearance of large unilamellar vesicles.

@article{Kao1981InteractionsOL,
  title={Interactions of liposomes with the reticuloendothelial system. Effects of reticuloendothelial blockade on the clearance of large unilamellar vesicles.},
  author={Y. J. Kao and Rudolph L Juliano},
  journal={Biochimica et biophysica acta},
  year={1981},
  volume={677 3-4},
  pages={
          453-61
        }
}
Large unilamellar liposomes (also called reversed phase vesicles or REVs) composed of DPPC and cholesterol are cleared from the circulation of the rat by a process which closely resembles the clearance of colloidal particles by the reticuloendothelial system. Thus, increasing the total amount of REVs administered by giving a loading dose of unlabelled REVs slows the clearance of a test dose of radioactively labelled REVs. This resembles the reticuloendothelial 'blockade' induced by large doses… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

Liposomal Simvastatin Attenuates Neointimal Hyperplasia in Rats

  • The AAPS Journal
  • 2010
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…